Particle motion trajectory tracking based on fiber optic tweezers

Abstract:

A biosensor based on single-fiber optical tweezers is proposed, which can detect the motion trajectory of cells based on the stable capture and transmission of silica microspheres as well as biological yeast cells by using a tapered optical fiber as a sensing element. The interference cavity is formed by using the fiber tip and the target particle, the detected interference signal is demodulated using Hilbert transform, and the displacement curve of the particle is plotted to realize the particle motion trajectory tracking. This method provides potential technical support for process monitoring of targeted drug delivery in biomedicine.