Home > Archive>Volume 15, Issue 6, 2019 >476. DOI:https://doi.org/10.1007/s11801-019-9147-5
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Fiber-coupler-based microfluidic system for trapping of DNA biomolecules
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1. Tianjin Key Laboratory of Optoelectronic Detection Technology and Systems, Tianjin Key Laboratory of Engineering Technologies for Cell Phamaceutica, College of Electronic and Information Engineering, Tianjin Polytechnic University, Tianjin 300387, China;2. Key Laboratory of Computer Vision and Systems, Ministry of Education, School of Computer Science and Engineering, Tianjin University of Technology, Tianjin 300384, China;3. Key Laboratory of Optoelectronic Sensor and Sensing Network Technology, College of Electronic Information and Optical Engineering, Nankai University, Tianjin 300350, China

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    Abstract:

    A miniature fiber-coupler-based microfluidic system is proposed for trapping of DNA biomolecules. The loop-shaped fiber-coupler is fabricated by using flame tapering technique and integrated in a microfluidic channel. Probe-DNA immobilized on the fiber-coupler surface enables specific recognition of target DNA sequences and effectively facilitates the trapping of target DNA molecules. The binding characteristics of biomolecules on the fiber-coupler surface have been theoretically analyzed and experimentally demonstrated. Experimental results indicate that the spectral response of the loop-shaped fiber coupler immobilized with probe DNA exhibits a red-shift with the trapping of the DNA biomolecules. The proposed microfluidic system possesses such desirable merits as simple structure, label-free method and high integration, which make it a promising candidate for applications in molecular biology and related bioengineering areas.

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WU Ji-xuan, WANG Qian, SONG Bin-bin, LIU Bo, ZHANG Hao, ZHANG Cheng, DUAN Shao-xiang, BAI Hua. Fiber-coupler-based microfluidic system for trapping of DNA biomolecules[J]. Optoelectronics Letters,2019,15(6):476-

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History
  • Received:September 06,2019
  • Revised:September 12,2019
  • Online: May 01,2020
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